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KMID : 0377619750290010033
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Korean Jungang Medical Journal
1975 Volume.29 No. 1 p.33 ~ p.40
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Antimicrobial Resistance and Resistance Transfer of Urinary Pathogens.
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Abstract
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Urinary infection is one of the major problems in urology, and the infection was known to be most frequently caused by Gram-negative bacilli. It was also known that the infection does not respond well to the antimicrobial treatment, positively due to the resistance of the organisms to drugs. This report describes the resistance of Gram-negative urinary pathogens to antimicrobial agents of current use, and the transferability of their resistance to Escherichia coli by conjugation.
A total of 42 strains of organisms isolated from urines of various urinary infections consisting of 16 E. coli, 6 Klebsiella, 5 Enterobacter, 6 Pseudomonas and 9 unidentified organisms, were tested for their antimicrobial resistance by agar dilution method. Most E. coli strains were susceptible to polymyxin B (PB), colistin (COL), nalidixic acid (NA), and trimethoprim-sulfamethoxazole compound (T MP-SMZ, 1 : 20). They were highly resistant to tetracycline (TC), chlorampheni￢col (CM), streptomycin (SM) and sulfisomidine (SA), and a little less resistant to
kanamycin (KM) and ampicillin (AP). Except for some strains less resistant to PB and COL, all strains of Klebsiella and Pseudomonas were highly resistant to antimicrobial agents tested. Most Enterobacter strains were susceptible to the an￢timicrobial drugs tested other than TC, CM, SM and SA. The resistance of un￢
identified urinary organisms was varaible.
Resistance of TC, CM, SM and SA of E. coli and Enterobacter isolated from urine can be transferred by conjugation to E. coli ML 1410 met- Lac+ NA´. The resistance can be transferred in urine of healthy persons at 37 C as well as 25 C and 42 C.
The resistance transfer of Klebsiella and Pseudomonas could not be tested without having suitable recipient strains.
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